Naturally restores a healthy mood†
When your emotions are healthy & balanced, you feel like yourself. Everyday tasks seem easy and you feel like you are in control. However, sometimes emotions can get out of balance, causing you to feel moody.†

What most people don't know is this imbalance can be associated with low levels of SAM-e (S-adenosylmethionine), a naturally occurring molecule produced by your body. SAM-e helps to maintain healthy emotions, but your SAM-e levels can run low due to various factors such as diet and aging.†

Now you can replenish your SAM-e levels by taking Nature Made® SAM-e Complete®. SAM-e has been proven to restore a healthy mood in as little as 7-14 days when taken daily.†

Promotes joint health†
Because SAM-e is naturally produced in your body, it also has other vital functions aside from helping to maintain healthy emotions. One of these other functions is to promote joint health, which naturally deteriorates with physical activity and age.†

*Complete because SAM-e has been clinically proven to benefit body functions including mood support & joint comfort.†

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested Use:
Start with 1 tablet per day. The best time to take SAM-e is on an empty stomach at least 30 minutes before a meal. Clinical studies indicate that benefits are most likely evident after 7-14 days of supplementation. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To determine the proper level of supplementation that works for you, gradually increase the number of tablets (maximum 1600 mg/day) until benefits are achieved.

Supplement Facts:
Serving Size: 1 Tablet
Servings Per Container: 48
Amount Per Tablet - % Daily Value:
SAM-e (S-adenosylmethionine) 400 mg - **.

**Daily Value not established.

Ingredients:
S-adenosylmethionine Tosylate Disulfate, Cellulose Gel, Methacrylic Acid Copolymer, Gylcerol Behenate, Talc, Triethyl Citrate, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide (artificial color), Mannitol, Glycerol Palmitostearate, Medium Chain Triglycerides, Sodium Starch Glycolate, Yellow 5.

This product is gluten and yeast free.

SAM-e is a moisture sensitive product. That is why at Nature Made®, we use foil blister packaging to ensure that each tablet of our SAM-e Complete® is fresh and safe when you take it.

Caution:
Foil blister pack ensure safety and freshness. Do not use if tamper evident printed on foil seal over tablets is broken. Store in a cool, dry place, out of reach of children.

People with bipolar (manic) depression should not take this or any other product containing SAM-e except under a doctor's supervision.

If you are pregnant or nursing, or taking prescription antidepressant medications, consult your doctor before using this product.

From Wikipedia, the free encyclopedia

Biochemistry of S-adenosyl methionine

[edit]SAM cycle

The reactions that produce, consume, and regenerate SAM are called the SAM cycle. In the first step of this cycle, the SAM-dependent methylases (EC 2.1.1) that use SAM as a substrate produceS-adenosyl homocysteine as a product.^[2] This is hydrolysed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase EC 3.3.1.1 and the homocysteine recycled back to methionine through transfer of a methyl group from 5-methyltetrahydrofolate, by one of the two classes of methionine synthases (EC 2.1.1.13 or EC 2.1.1.14). This methionine can then be converted back to SAM, completing the cycle.^[3]

[edit]Polyamine biosynthesis

Another major role of SAM is in polyamine biosynthesis. Here, SAM is decarboxylated by adenosylmethionine decarboxylase (EC 4.1.1.50) to form S-adenosylmethioninamine. This compound then donates its n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine.^[4]

SAM is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and neurotransmitters that affect mood, such as dopamine and serotonin. Methyltransferases are also responsible for the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.^[5][6]

Therapeutic uses

In the United States and Canada, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled SAME or SAMe; pronounced "sam ee" or "Sammy"). SAM is also marketed under the Gumbaral, Samyr, Adomet, Heptral and Admethionine brand names as a prescription drug approved in Russia, Italy, and Germany. Some research, including multiple clinical trials, has indicated that taking SAM on a regular basis may help fight depression,^[7][8][9] liver disease, and the pain ofosteoarthritis.^[10] All other indications are not yet proven.

Therapeutic use of SAM has increased as dietary supplements have gained in popularity, especially after the Dietary Supplement Health and Education Act was passed in 1994. This law allowed the distribution of SAM as a dietary supplement, and therefore allowed it to bypass the regulatory requirements for drugs of the Food and Drug Administration (FDA).

At first, a line of evidence suggested that abnormally low levels of endogenous SAM may play an important role in the development of Alzheimer's disease (AD) and that SAM may therefore have therapeutic potential in the treatment of AD. However, further research has indicated this effect is likely due to vitamin B₁₂ deficiencies, which cause neurologic defects through one carbon transfers with folate. Severely low levels of SAM have been found in the cerebrospinal fluid^[11] and in all brain regions of AD patients examined.^[12] Preliminary research suggests SAM may have therapeutic potential in treating AD patients ^[13] and a recent study using a mouse model of AD found that supplementary SAM prevented oxidative damage and cognitive impairment.^[14